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Istvan Toth is a Chemical Engineer and an internationally recognized expert in drug delivery. His major research interests lies in immunoadjuvants, carbohydrates, lipids, peptides, nucleosides and nucleotides. He is a Fellow of the Royal Australian Chemical Institute, The Queensland Academy of Science and Art and The Hungarian Academy of Sciences.
Adjuvants are essential for enhancing and directing the adaptive immune response to vaccine antigens. The relationship between a vaccines physicochemical property and the type of immune response acquired is critical for the advancement of vaccine adjuvants. This underpins researcher’s goal to study the structure-activity relationship between self-adjuvanting lipid-based vaccine candidates containing ovalbumin (OVA) CD4 and CD8 peptide epitopes to determine the optimal architecture for stimulation of potent cell-mediated immune responses. Constructs that formed small nanoparticles showed higher cytolytic activity and enhanced tumour growth inhibition. Overall the investigation of the relationship between physicochemical properties self-assembled nanoparticles and immune response for new vaccine candidates is very important.