Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences
Khadija Rafiq has completed her PhD from Catholic University of Leuven, Belgium. She is assistant professor of Thomas Jefferson University, USA.
Heart failure (HF) is the final clinical entity of many diverse disease causes and mechanisms. HF refers to a state of inadequate cardiac function to maintain systemic perfusion at a rate commensurate with the requirements of the body at rest or during states of increased demand. Mortality is comparable to that of the most common cancers, with a 50% 5-year survival. Despite advances in our understanding of the pathophysiology and treatment of HF, this malady continues to be a major public health burden with an enormous impact on the cost of healthcare. Current research efforts are focused on understanding novel mechanisms and signaling pathways. Immune activation and inflammation have been postulated as important pathophysiological events in this process. Cardiac inflammation is major pathophysiological mechanism operating in the failing heart, regardless of HF etiology. Experimental and clinical studies have suggested that inflammation in the development of heart failure is related to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Furthermore, disturbances of the cellular and humoral immune system are frequently observed in heart failure. Therefore, it is essential to understand the immunological mechanisms involved in HF in order to develop useful therapies against the life threatening disorder.