Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

Biography

Dr. Godwin W Nchinda (Ph.D) is Senior Immunologist CIRCB and Deputy Director General Head of CIRCB Vaccinology Laboratory Head of CIRCB Biobanking Laboratory For the last twenty four years I have focused my attention to developing model vaccines that could be easily translated into clinics against infectious diseases and tumors. I studied Microbiology in the University of Calabar, Nigeria and then spent four years thereafter in the University of Nigeria, Nsukka, Nigeria working on an NIH Grant where we developed a feed based vaccine against Newcastle disease virus infections in free range Chickens. During my Ph.D thesis (1998-2001) I learned how to design and evaluate model SIV/HIV vaccines under the mentorship of Dr. K. Überla, Professor of Molecular Virology in the University of Leipzig Germany. I next did a two year postdoc in the Ruhr University Bochum, Germany where we continued characterizing HIV/SIV vaccines. During the next 7 years (2003-2010), I worked under the mentorship of Dr. Ralph Steinman (2011 Nobel prize for Medicine) of the Rockefeller University USA, where we developed new forms of HIV, TB, Malaria and Tumor vaccines by harnessing Dendritic cells. In 2008 I was certified as a clinical and translational research scientist by the Rockefeller University. In 2010 I relocated to CIRCB, Yaounde Cameroon where we are now optimizing dendritic cell targeted vaccines for clinical evaluation in Africa. The first in human evaluation of a Cameroon developed HIV-1 vaccine is envisaged in 2017. In addition we are also studying the phenotypic and functional properties of various immune’s cells in the context of co-morbidies with HIV-1 infection. We are looking particularly at the impact of malaria, HBV, HCV, HPV and TB in the long term management of HIV-1 especially in remote areas of Africa. We are also actively training young research scientists at the Msc and Ph.D level to perform cutting edge science. Our work has been funded by TWAS, EDCTP, Canada grand challenge, Italy, Germny, Korea and Norway. Never the less the the Cameroonian government has remain our greatest funder.

Abstract

Background: The membrane proximal external region (MPER) of HIV-1 envelope glycoprotein-41 (gp41) is targeted by several broadly neutralizing antibodies whose conserved linear epitopes are promising targets for vaccine design. However, a formidable challenge has remained the difficulty to design and deliver MPER based immunogens for the efficient induction of such broadly neutralizing HIV-1 specific antibodies (bnAb). This is mainly because the linear bnAb MPER epitopes are poorly accessible to the immune system. The overall objective of this study therefore was the development and validation of an RNA coliphage Q? display system for efficient presentation of conserved bnAb epitopes to the immune system Method: To overcome the challenge of effective presentation of MPER to the immune system we have selectively engineered the surface of the RNA coliphage Q? to to display a 51 aa consensus MPER peptide upon the surface of the phage particle. The expression cassettes were used for the production of Q?MPER recombinant hybrid phages after transformation of E. coli HB101 strain. Results:Specific recognition of all the linear MPER based bnAb epitopes were confirmed in ELISA with recombinant Q?MPER phage as antigen and the bnAb 2F5, Z13, 4E10 and 10E8 as antibodies. Next the prevalence of MPER specific antibodies was determined in plasma from antiretroviral naïve HIV infected participants of the CIRCB AFRODEC cohort. The greater majority (84%) of participants’ plasma showed MPER peptide specific reactivity with antibody titers ranging ranging from 200 to 409600 comparative to background values with Q? empty as antigen. Conclusion:Thus, this novel recombinant Q?MPER phages can be used to monitor MPER- specific immune responses in clinical samples. In addition the recombinant Q?MPER phage can be used as immunogens either alone or in combination with other strategies for the induction of MPER specific immunity against HIV-1.

Speaker Presentations

Speaker Presentations

Speaker PDFs

Allied Academies Global Conference Directory

Mail us at

Program Enquiry
infectiousdiseases@alliedconferences.org
Sponsorship opportunity
infectiousdiseases@alliedconferences.org
General Enquiry
infectiousdiseases@alliedannualsummit.com
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

The organizers holds no responsibilities or liabilities of the personal articles of attendees at the venue against any kind of theft, lost, damage, due to any reason whatsoever. Delegates are entirely responsible for the safety of their own belongings.

 

Insurance

No insurance, of any kind, is included along with the registration in any of the events of the organization.

 

Transportation

Please note that transportation and parking is the responsibility of the registrant, Allied Academies will not be liable for any actions howsoever related to transportation and parking.

 

Press/Media

Press permission must be obtained from Allied Academies Conference Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party non-profit organization and this conference is not associated with any commercial meeting company.

 

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference after payment of complete registration fee. Once registration is complete, please contact infectiousdiseases@alliedconferences.org to request for a personalized letter of invitation, if not received until one month before the scheduled date of event.

All the bank charges applicable during refund will be deducted from the account of participant.

 

Cancellation Policy

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

 

Postponement of event

If, due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within period of one year from the date of rescheduling.

 

Transfer of registration

All registrations, after payment of complete registration fee, are transferable to other persons from the same organization, if in case the person is unable to attend the event. Request for transfer of registration must be made by the registered person in writing to contact@alliedacademies.com . Details must include the full name of replaced new registrant, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if intimated within 14 days of respective conference.

The transferred registrations will not be eligible for Refund.

This cancellation policy was last updated on April 04, 2015.

 

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues are not covered under the cancellation policy of Allied academies, including the inability to obtain a visa.

 

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund policies apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overhead charges, following Refund Policy Orders are available:

  • Before 60 days of the conference: Eligible for Full Refund after deduction of $100 towards service Fee.
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

 

Accommodation Cancellation Policy:

Accommodation Service Providers (Hotels) have their own cancellation policies which are applicable when cancellations are made less than 30 days prior to arrival. If in case the registrant wishes to cancel or amend the accommodation, he/ she is expected to inform the organizing authorities on a prior basis. Allied academies will advise the registrant to ensure complete awareness about the cancellation policy of your accommodation provider, prior to cancellation or modification of their booking.

Copyright © 2018-2019 Allied Academies, All Rights Reserved.